Dominic Ng
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Cytoskeleton regulation and signal transduction
Microtubules, actin and intermediate filaments together make up the cytoskeleton in mammalian cells, which is linked to all cellular processes including differentiation, migration and division. In response to cellular cues or signals, cytoskeletal filaments can assemble, disassemble and reorganize very rapidly. To facilitate such dynamic shifts, a complex network of regulatory proteins integrates these signals to control cytoskeletal dynamics.
Our lab investigates how conserved intracellular signalling pathways regulate key cytoskeletal regulatory proteins to effect changes in cellular architecture and function. We are particularly interested in how these same signalling pathways often go “haywire” during injury and disease and determining how a dysregulated cytoskeleton contributes to disease pathology. Our goal is to provide a detailed mechanistic understanding of what goes wrong in disease at the molecular and cellular level using a combination of biochemical and molecular cell biology approaches.
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