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Many human diseases, notably those that cause degeneration of the brain, such as Huntington’s and motor neuron disease, involve the abnormal aggregation of proteins into large clumps inside cells or in the tissue surrounding them. Our lab investigates the consequences of protein misfolding and aggregation on the operation of cells. We also study processes by which cells attempt to counteract aggregation by employing protein quality control machinery, such as chaperones. A key plank of our efforts is the development of new methods and approaches that enable us to view the protein aggregation landscape in a cell at molecular resolution. We have built, and are continuing to build, new biosensors to probe cell pathways and physiological processes.
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