Marie Bogoyevitch
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Signal transduction in health and disease
We study the intracellular signalling pathways that regulate the responses of cells to changes in their environment, some of which are associated with dramatic alterations in gene expression.
In particular, we are studying how changes in the level of the transcription factor STAT3 affect its localisation to the nucleus and regulation by phosphatases, as well as the profiles of gene expression in response to cytokines or environmental stresses.
Protein kinases are also important in regulating the cell's response to cytokines, hormones and stress. We are undertaking research to define how c-Jun N-terminal Kinases (JNKs) contribute to the balance between cell survival and cell death under different conditions. Our approach is to identify new proteins that interact with JNKs and the substrates for JNKs. Such first steps will provide information about potential interventions capable of modifying JNK metabolism as the basis for future therapies for a range of diseases, including cancer, cardiovascular disease, and diabetes.
We use a combination of molecular and cellular approaches to learn more about signal transduction mechanisms.
Current project areas:
- The regulation of STAT3 and its transcriptional targets: implications for transcriptional events during exposure to cytokines and stress
- Definition of the JNK-interactome: identification of regulators and mediators of JNK signalling
- Evaluation of the actions of a neuroprotective peptide that inhibits JNK: improving our understanding of the molecular events in stroke
- Identifying proteins that interact with JNK: implications for understanding diverse stress-activated events such as microtubule organisation and the ER stress response.