Faculty of Medicine, Dentistry & Health Science Department of Biochemistry and Molecular Biology

Publications 2006

  1. Adamson PJ, Millard DJ, Hohmann AW, Mavrangelos C, Macardle PJ, Mulhern T, Nicholson IC, Pilkington G, Tedder TF & Zola H. (2006) 'Improved antigen binding by a CD20-specific single-chain antibody fragment with a mutation in CDRH1', Mol Immunol, 43(6), 550-558.
  2. Aggarwal A, Guo DL, Hoshida Y, Yuen ST, Chu , So S, Boussioutas A, Chen X, Bowtell D, Aburatani H, Leung SY, Tan P. (2006) 'Topological and functional discovery in a gene coexpression meta-network of gastric cancer', Cancer Res, 66 (1), 232-241.
  3. Andersen OM, Schmidt V, Spoelgen R, Gliemann J, Behlke J, Galatis D, Mckinstry WJ, Parker MW Masters CL, Hyman BT, Cappai R, Willnow TE. (2006) 'Molecular dissection of the interaction between APP and its neuronal trafficking Receptor SorLA/LR11', Biochemistry, 45, 2618-2628.
  4. Bathgate R, Du XJ, Samuel C, Summers RJ. (2006) ''Relaxin' the stiffened heart and arteries: The therapeutic potential for relaxin in the treatment of cardiovascular disease', Pharmacol Therapeutics, 112(2), 529-552.
  5. Bathgate R, Hsueh AJW, Layfield S, Scott DJ, Sudo S, Tregear G, Yan Y. (2006) 'Characterization of novel splice variants of LGR7 and LGR8 reveals that receptor signaling is mediated by their unique low density lipoprotein class A modules', J Biol Chem, 281 (46), 34942-34954.
  6. Bay BH, Cheng H, Cheung NS, Choy MS. (2006) 'PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis', Neuroscience Letters, 405, 120-125.
  7. Brazier M, Lewis V, Ciccotosto G, Klug G, Lawson V, Cappai R, Ironside J, Masters C, Hill A, White A, Collins S. (2006) 'Correlative studies support lipid peroxidation is linked to PrPres propogation as an early primary pathogenic event in prion disease', Brain Res Bull, 68, 346-354.
  8. Burri L, Vascotto K, Gentle IE, Chan NCK, Beilharz T, Stapleton D, Lithgow T, Ramage L. (2006) 'Integral membrane proteins in the mitochondrial outer membrane of Saccharomyces cerevisiae', FEBS J, 273(7), 1507-1515.
  9. Burri L, Williams BAP, Bursac D, Lithgow T, Keeling PJ. (2006) 'Microsporidian mitosomes retain elements of the general mitochondrial targeting system', Proc Nat Acad Sci, USA, 103(43), 15916-15920.
  10. Chan N, Likic V, Waller R, Mulhern T, Lithgow T. (2006) 'The C-terminal TPR domain of Tom70 defines a family of mitochondrial protein receptors found only in animals and fungi', J Mol Biol, 358, 1010-1022.
  11. Chen L, Colman PM, Fairlie WD, Huang DCS, Kvansakul M, Perugini M. (2006) 'CED-4 forms a 2 : 2 heterotetrameric complex with CED-9 until specifically displaced by EGL-1 or CED-13', Cell Death Differ, 13, 426-434.
  12. Chong YP, Chan AS, Chan KC, Williamson N, Lerner EC, Smithgall TE, Bjorge JD, Fujita DJ, Purcell A, Scholz G, Mulhern T, Cheng H. (2006) 'C-terminal Src Kinase-homologous Kinase (CHK), a Unique Inhibitor Inactivating Multiple Active Conformations of Src Family Tyrosine Kinases', J Biol Chem, 281(44), 32988-32999.
  13. D'Auvergne EJ, Gooley P. (2006) 'Model-free model elimination: a new step in the model-free dynamic analysis of NMR relaxation data', J Biomol NMR, 35(2), 117-35.
  14. De Souza DP, Ellis M, Emanuela E, Joan J, Mcconville M, Naderer T, Sernee M. (2006) 'Virulence of Leishmania major in macrophages and mice requires the gluconeogenic enzyme fructose-1,6-bisphosphatase', Proc Nat Acad Sci, USA, 103(14), 5502-5507.
  15. De Souza DP, Likic V, Mcconville M, Saunders EC. (2006) 'Progressive peak clustering in GC-MS Metabolomic experiments applied to Leishmania parasites', Bioinformatics, 22(11), 1391-1396.
  16. Distel LVR, Neubauer s, Keller U, Sprung C, Sauer R, Grabenbauer GG. (2006) 'Individual differences in chromosomal aberrations after in vitro irradiation of cells from healthy individuals, cancer and cancer susceptibility syndrome patients', Radiother Oncol, 81(3), 257-263.
  17. Doganay GM, Khodr B, Georgiou G, Khalil Z. (2006) 'Pharmacological manipulation of the vasoconstrictive effects of amyloid-beta peptides by donepezil and rivastigmine', Curr Alzheimer Res, 3, 137-145.
  18. Dolezal P, Likic V, Tachezy J, Lithgow T. (2006) 'Evolution of the molecular machines for protein import into mitochondria', Science, 313(5785), 314-318.
  19. Dow LE, Kauffman JS, Caddy J, Peterson AS, Jane SM, Russell SM, Humbert PO. (2006) 'The tumour-suppressor Scribble dictates cell polarity during directed epithelial migration: regulation of Rho GTPase recruitment to the leading edge', Oncogene, epub 2006 Oct 9.
  20. Du XJ, Gao XM, Kiriazis H, Moore XL, Ming Z, Su Y, Finch AM, Dart AM, Graham RM, Hannan R. (2006) 'Transgenic a1A-adrenergic activation limits post-infarct ventricular remodeling and dysfunction and improves survival', Cardiovasc Res, 71(4), 735-743.
  21. Ely LK, Beddoe T, Clements CS, Matthews JM, Purcell A, Mccluskey J, Kjer-Nielsen L, Rossjohn J. (2006) 'Disparate thermodynamics governing T cell receptor–MHC-I interactions implicate extrinsic factors in guiding MHC restriction', Proc Nat Acad Sci USA, 103(17), 6641-6646.
  22. Francis CJ, Lindorff-Larsen K, Best RB, Vendruscolo M. (2006) 'Characterization of the residual structure in the unfolded state of the Delta 131 Delta fragment of staphyloccocal nuclease', Proteins - Struct Funct Bioinformatics, 65(1), 145-152.
  23. French JD, Dunn J, Smart CE, Manning N, Brown M. (2006) 'Disruption of BRCA I function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines', Genes, Chromosomes Cancer, 45(3), 277-289.
  24. Fu P, Shen PJ, Zhao CX, Scott DJ, Samuel C, Wade J, Tregear G, Bathgate R, Gundlach A. (2006) 'Leucine-rich repeat-containing G-protein-coupled receptor 8 in mature glomeruli of developing and adult rat kidney and inhibition by insulin-like peptide-3 of glomerular cell proliferation', J Endocrinol, 189, 397-408.
  25. Gerrard JA, Mckerchar HJ, Pearce FG, Perugini M. (2006) 'Dihydrodipicolinate synthase from Thermotoga maritima', Biochem J, 400, 359-366.
  26. Godfrey D, McConville M, Pellicci D. (2006) 'Chewing the fat on natural killer T cell development', J Exptal Med, 203(10), 2229-2232.
  27. Goffin L, Vodala S, Dyke CL, Timms M, Meusburger S, Catimel B, Nice E, Silver PA, Xiao C, Jans DA, Gething M. (2006) 'The unfolded protein response transducer Ire1p contains a nuclear localisation sequence recognised by multiple beta importins', Mol Biol Cell, 17, 6309-5323.
  28. Gralle M, Oliveira CLP, Guerreiro LH, Mckinstry WJ, Galatis D, Master CL, Cappai R, Parker MW, Ramos CHI, Torriani I, Ferriera ST. (2006) 'Solution conformation and heparin-induced dimerization of the full-length extracellular domain of the human Amyloid Precursor Protein', J Mol Biol, 357, 493-508.
  29. Grollo L, Torresi J, Drummer H, Zeng W, Williamson N & Jackson D. (2006) 'Exploiting information inherent in binding sites of virus-specific antibodies: design of an HCV vaccine candidate cross-reactive with multiple genotypes', Antiviral Ther, 11(8), 1005-1014.
  30. Hawthorne R, Cromer BA, Ng H, Parker M, Lynch JW. (2006) 'Molecular determinants of ginkgolide binding in the glycine receptor pore', J Neurochem, 98(2), 395-407.
  31. Hewitson T, Mookerjee I, Masterson , Zhao , Tregear G, Becker G, Samuel C. (2006) 'Endogenous relaxin is a naturally occurring modulator of experimental renal tubulointerstitial fibrosis', Endocrinol, 148(2), 660-669.
  32. Hill E, Krebs B, Goodall D, Howlett G, Dunstan D. (2006) 'Shear flow induces amyloid fibril formation', Biomacromols, 7(1), 10-13.
  33. Holloway A, Diyagama DS, Opeskin K, Creaney J, Robinson BWS, Lake RA, Bowtell D. (2006) 'A molecular diagnostic test for distinguishing lung adenocarcinoma from malignant mesothelioma using cells collected from pleural effusions', Clin Cancer Res, 12(17), 5129-5135.
  34. House CM, Hancock NC, Moller A, Cromer BA, Fedorov V, Bowtell DDL, Parker M, Polekhina G. (2006) 'Elucidation of the substrate binding site of siah ubiquitin ligase', Structure, 14(4) 695-701.
  35. Howlett G, Minton AP, Rivas G. (2006) 'Analytical ultracentrifugation for the study of protein association and assembly', Curr Opin Chem Biol, 10(5), 430-436.
  36. Howlett G, Mok Y. (2006) 'Sedimentation velocity analysis of amyloid oligomers and fibrils', Methods Enzymol, 413, 199-217.
  37. Howlett G, Moore KJ. (2006) .Untangling the role of amyloid in atherosclerosis., Curr Opin Lipidol, 17(5), 541-547.
  38. Iacovache I, Lesieur C, Matile S, Parker M, Paumard P, Sakai N, Scheib H, Van Der Goot FG. (2006) 'A rivet model for channel formation by aerolysin-like pore-forming toxins', EMBO J, 25, 457-466.
  39. Jabbour A, Puryer A, Yu Y, Lithgow T, Riffkin , Ashley D, Vaux L, Ekert P, Hawkins C. (2006) 'Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1homologue CED-4, but can interact with EGL-1', J Cell Sci, 119, 2572-2582.
  40. James PF, Perugini M, O'Hair R. (2006) 'Sources of artefacts in the electrospray ionization mass spectra of saturated diacylglycerophosphocholines: from condensed phase hydrolysis reactions through to gas phase intercluster reactions', J Am Soc Mass Spectrom, 17, 384-394.
  41. Jiang S, Rhee SW, Gleeson P, Storrie B. (2006) 'Capacity of the Golgi apparatus for cargo transport prior to complete assembly', Mol Biol Cell, 17(9), 4105-4117.
  42. Juraja SM, Mulhern T, Hudson PJ, Hattarki MK, Carmichael JA, Nuttall SD. (2006) 'Engineering of the Escherichia coli Im7 immunity protein as a loop display scaffold', Prot Engineer Design Select, 19 231-244.
  43. Kaparakis M, Laurie K, Wijburg O, Pedersen J, Pearse M, Van Driel I, Gleeson P, Strugnell R. (2006) 'CD4+ CD25+ regulatory T cells modulate the T-cell and antibody responses in Helicobacter-infected BALB/c mice', Infection Immun, 74(6), 3519-3529.
  44. Kedzierski L, Malby RL, Smith BJ, Perugini M, Hodder AN, Ilg T, Colman P, Handman E. (2006) 'Structure of Leishmania mexicana phosphomannomutase Hhighlights similarities with human isoforms', J Mol Biol, 363(1), 215-227.
  45. Ke H, Zhang S, Li J, Howlett G, Wang CC. (2006) 'Folding of Escherichia coli DsbC: characterization of a monomeric folding intermediate', Biochemistry, 45(50), 15100-15110.
  46. Kerr MC, Lindsay MR, Luetterforst R, Hamilton N, Simpson F, Parton R, Gleeson P, Teasdale RD. (2006) V'isualisation of macropinosome maturation by the recruitment of sorting nexins', J Cell Sci, 119(19), 3967-3980.
  47. Kovacevic S, Anderson D, Morita Y, Patterson J, Haites RE, Mcmillan BNI, Coppel R, Mcconville M, Billman-Jacobe H. (2006) 'Identification of a novel protein with a role in lipoarabinomannan biosynthesis in mycobacteria', J Biol Chem, 281(14), 9011-9017.
  48. Krishhnamurthy , Dudek L, Mckenzie D, Purcell A, Brooks A, Colman P, Harrison C, Lew , Thomas E, Kay E. (2006) 'Responses against islet antigens in NOD mice are prevented by tolerance to proinsulin but not IGRP', J Clin Invest, 116(12), 3258.
  49. Krisnamurthy B, Dudek N, Mckenzie M, Purcell A, Brooks A, Gellert S, Colman P, Harrison L, Lew A, Thomas H, Kay T. (2006) 'Responses against islet antigens in NOD mice prevented by tolerance to proinsulin but not IGRP', J Clin Invest, 116(12), 3258-3264.
  50. Li R, Soosairajah J, Harari D, Citri A, Price J, Ng H, Morton CJ, Parker M, Yarden Y, Bernard O. (2006) 'Hsp90 increases LIM kinase activity by promoting its homo-dimerization', FASEB J, 20, 1218-1220.
  51. Lister K, Autelitano DA, Jenkins A, Hannan R, Sheppard KE. (2006) 'Cross talk between corticosteroids and alpha-adrenergic signalling augments cardiomyocyte hypertrophy: A possible role for SGK1', Cardiovasc Res, 70(3), 555-565.
  52. Livett B, Sandall D, Keays D, Down J, Gayler K, Satkunanathan N, Khalil Z. (2006) 'Therapeutic applications of conotoxins that target the neuronal nicotinic acetylcholine receptor', Toxicon, 48, 810-829.
  53. Livett B, Sandall DW, Keays DA, Down J, Gayler K, Satkunanathan N. Khalil Z. (2006) 'Therapeutic applications of conotoxins that target the neuronal nicotinic acetylcholine receptor', Toxicon, 48, 810-829.
  54. Masters C, Cheng H, Mok S, Hill A, Lio S. (2006) 'C-terminal truncation and Parkinson's disease-associated mutations down regulate the protein serine/threonine kinase activity of PTEN-induced kinase-1', Hum Mol Gen, 15(21), 3251-3262.
  55. Miller RE, McConville M, Woodrow I. (2006) 'Cyanogenic glycosides from the rare Australian endemic rainforest tree Clerodendrum grayi (Lamiaceae)', Phytochem, 67, 43-51.
  56. Morita YS, Sena CBC, Waller R, Kurokawa K, Sernee M, Nakatani F, Haites R, Billman-Jacobe H, Mcconville M, Kinoshita T, Maeda Y. (2006) 'PimE is a polyprenol-phosphate-mannose-dependent mannosyltransferase that transfers the fifth mannose of phosphatidylinositol mannoside in mycobacteria', J Biol Chem, 281(35), 25143-25155.
  57. Perry A, Hulett JM, Likic V, Lithgow T, Gooley P. (2006) 'Convergent evolution of receptors for protein import into mitochondria', Curr Biol, 16(3), 221-229.
  58. Phillips W, Rusell SE, Ciavarella ML, Choong DYH, Smith K, Campbell IG, Pearson R, Thomas R, Montgomery KG. (2006) 'Mutation Analysis of PIK3CA and PIK3CB in esophageal cancer and Barrett's esophagus', Internat J Canc, 118, 2644-2646.
  59. Prapunpoj p, Leelawatwatana L, Schreiber G, Richardson S. (2006) 'Change in structure of the N-terminal region of transthyretin produces change in affinity of transthyretin to T4 and T3', FEBS J, 273(17), 4013-4023.
  60. Puryer MA, Jabbour AM, Yu JY, Lithgow T, Riffkin CD, Ashley DM, Ekert PG, Vaux DL, Hawkins CJ. (2006) 'Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1', J Cell Sci, 119, 2572-2582.
  61. Rudge G, Gleeson P, Van Driel I. (2006) 'Control of immune responses by immunoregulatory T cells', Archiv Immunol Ther Experimntalis, 54 6), 381-391.
  62. Sernee M, Ralton J, Dinev Z, Khairallah G, O'Hair R, Williams S, Mcconville M. (2006) 'Leishmania ß-1,2-mannan is assembled on a mannose-cyclic phosphate primer', Proc Nat Acad Sci USA, 103(25), 9458-9463.
  63. Shabanpoor F, Bathgate R, Hossain M, Giannakis E, Wade J, Hughes R. (2006) 'Design, synthesis and pharmacological evaluation of cyclic mimetics of the insulin-like peptide 3 (INSL3) B-chain', J Peptide Sci, 13, 113-120.(Not Final)
  64. Smith D, Smith DG, Curtain C, Boas F, Pilbrow R, Ciccotosto G, Lau TL, Tew D, Perez K, Wade J, Bush A, Drew C, Separovic F, Masters C, Cappai R, Barnham K. (2006) 'Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge', J Biol Chem, 281(22), 15145-15154.
  65. Tellez-Sanz R, Cesareo E, Aguilera AM, Baron C, Parker LJ, Adams JJ, Morton CJ, Lo Bello M, Parker M, Garcia-Fuentes L. (2006) 'Calorimetric and structural studies of the nitric oxide carrier S-nitrosoglutathione bound to human glutathione transferase P1-1', Protein Sci, 15, 1093-1105.
  66. Tinker V, Boussioutas A, Bowtell D. (2006) 'The challenges of gene expression microarrays for the study of human cancer', Canc Cell, 9(5), 333-339.
  67. Uboldi AD, Lueder FB, Walsh P, Spurck T, Mcfadden G, Curtis J, Likic V, Perugini M, Barson M, Lithgow T, Handman E. (2006) 'A mitochondrial protein affects cell morphology, mitochondrial segregation and virulence in Leishmania', Internat J Parasitol, 36(14), 1499-1514.
  68. Van Der Peet P, Gannon C, Walker I, Dinev Z, Angelin B, Tam S, Ralton J, Mcconville M, Williams S. (2006) 'Use of click chemistry to define the substrate specificity of Leishmania -1,2-mannosyltransferases', ChemBioChem, 7(9), 1384-1391.
  69. Wade J, Hojo , Kawasaki K, Johns T, Catimel B, Rothacker J, Nice E. (2006) 'An automated peptide and protein thiazolidine coupling chemistry for biosensor immobilization giving a unique N-terminal orientation', Anal Biochem, 348(2), 315-317.
  70. Wang Y, Harley V, Ristevski S. (2006) 'SOX13 exhibits a distinct spatial and temporal expression pattern during chondrogenesis, neurogenesis and limb development', J Histochem Cytochem, 54(12), 1327-1333.
  71. Williamson N, Rossjohn J, Purcell A. (2006) 'Tumors reveal their secrets to cytotoxic T cells', Proc Nat Acad Sci USA, 103(40), 14649-14650.
  72. Wilson LM, Pham C, Jenkins A, Wade JD, Hill A, Perugini M, Howlett G. (2006) 'High density lipoproteins bind Aß and apolipoprotein C-II amyloid fibrils', J Lipid Res, 47(4), 755-760.
  73. Zwar T, Read S, Van Driel I, Gleeson P. (2006) 'CD4+CD25+ regulatory T cells inhibit the antigen-dependent expansion of self-reactive T cells in vivo', J Immunol, 176(3), 1609-1617.
  74. Zwar T, Van Driel I, Gleeson P. (2006) 'Guarding the immune system: suppression of autoimmunity by CD4+CD25+ immunoregulatory T cells', Immunol Cell Biol, 84(6), 487-501.

Publications - 2004
Publications - 2005

top of page